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Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...The phase purity of the cocrystal samples prepared by rapid solvent evaporation and simple evaporation techniques was examined by PXRD based on the presence or absence of the characteristic peaks of the corresponding individual components ... Higuchi T, Connors KA. Phase-solubility techniques. Advan Anal Chem Instr. …The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a complex ...Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …

Solubility studies. The phase-solubility diagram corresponding to DPS:βCD system is illustrated in Fig. 5. It was performed according to the method reported by of Higuchi and Connors in order to determine the stability constant of the suggested complex and evaluate its stoichiometry. Measurements were made at 291 nm, which corresponds to the ...The effect of β-CD on the solubility of atorvastatin was investigated according to the phase solubility technique reported by Higuchi and Connors . Excess amounts of atorvastatin were added to 20 mL of either double-distilled water or aqueous solutions containing increasing concentrations of CDs, ranging from 5 to 15% w/w, in a …Solubility diagrams were obtained according to Higuchi and Connors (1965). Excess amounts of sulfamethizole were added to water containing various concentrations of cyclodextrins and the suspensions were shaken at 37°C. ... Phase solubility techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus Google Scholar. Job, …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. In vitro digestion showed that CDs protect the drug during digestion and even improve its bioaccessibility, and points to the need to protect roflumilast from light, suggesting that tablets containing the drug might be reformulated.

Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 2018 ; Higuchi & Connors 1965 ). Briefly, an excess of KME was added to 200 μL aqueous solutions of different HP-β-CD concentrations (1, 2, 4, 6, 8, and 10 mM).Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... ….

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Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.

To establish the increase of ezetimibe water solubility, caused by the influence of rising concentration of cyclodextrins in the aqueous solution, UV-VIS spectrophotometry measurements were performed . Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug ...One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. Guest–host interaction of astemizole (Astm) with cyclodextrins (CDs) has been investigated using phase solubility diagrams (PSD), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), proton nuclear magnetic resonance (1H-NMR) and molecular mechanical modeling (MM+). Estimates of the complex formation …

statistics sample problems Higuchi a nd K. A. Connors, “Phase-solubility techniques, ” Advanc es in Ana lyti cal Ch emi str y and Inst rume ntati on ,v o l . , p p . – , . what is formative evaluation in researchku 5 0 HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …To establish the increase of ezetimibe water solubility, caused by the influence of rising concentration of cyclodextrins in the aqueous solution, UV-VIS spectrophotometry measurements were performed . Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug ... characteristics of a good leader in education All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ... ku medical center shootingkungamegethro muscadin crash Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ... sayers bears Phase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1 ou ku game timekentucky ksriley spencer Abstract. The effect of polymers and various drugs on the solubility of β-cyclodextrin (βCD) was determined. The apparent stability constant (Kc) of the drug-βCD complex was calculated from the phase-solubility diagrams. The water solubility of βCD was determined to be 1.9% (w/v), but addition of 0.25-1% (w/v) of polyvinylpyrrolidone (PVP ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …